It refers to a group of haemopoietic stem cell disorder characterized by dysplastic and ineffective haematopoie leading to cytopenia  (anaemia, neutropenia and thrombocytopenia).

In course of time some of the patient of MDS evolved to acute leukemia.

FAB classification of MDS

            Type

Refractory anaemia (RA)

RA with ring sideroblast (RARS)

RA with excess blast (RAEB)

RA with excess blast transformation

Chronic myelomonocytic leukemia

Clinical features

nInsidious onset, occurs over 50 years age.

n

nCommon- Anaemia, Infection and hemorrhagic menifestation

Laboratory diagnosis

Blood picture- Hb- mild to moderate reduce

                       WBC- Leucopenia (Neutropenia)

PBF- RBC- Normocytic or mild macrocytic

                  and may be dimorphic. Nucleated                                         cells are also present

        WBC- Hypo or agranular granulocytes with bi-lobed nucleus (Pelger- Huet cell )

         Platelet- Reduced.

Bone marrow

Cellularity-  Hypercellular with disordered development of all series.

Erythropoisis- Megaloblastoid change, Multinucleated erythoblast, Nuclear budding, frequent mitosis, Howell-Jolly bodies are seen.

Granulopoisis- Hyperactive and shift to left . Blast cells are present(5- 30%).Maturation arrest at myelocytic stage.

Megakarryopoisis-Small and large monolobular megakarryocytes are present
  

Spirochetes:http://spirochetesinhuman.blogspot.com/

 

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